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Manual article review is required for this article
Manual article review is required for this article
CDK4-cyclin E complexes then kind, initiating G1/S changeover regulating centrosome duplication. Once DNA is replicated in S period, CDK1 is activated by binding to cyclin A or B, which encourages centrosome maturation and separation, 메이저사이트 chromosome condensation and mitotic exit next breakdown from the nuclear envelope.